TOKU-E Announces Ultrapure bio-Acrylamide for Electrophoresis and other Life Science Applications

TOKU-E Company has announced availability of their newly developed, Ultra-Pure, bioconversion acrylamide

TOKU-E Company has announced availability of their newly developed, innovative, ultra-safe, faster dissolving dust-free grade (DF) Sodium Dodecyl Sulfate (SDS).

Two manufacturing processes, chemical synthesis and enzyme conversion, make up current worldwide acrylamide production. Chemical synthesis of acrylamide involves adding water to acrylonitrile, usually catalyzed by the addition of Copper (Cu+). This widely used production method carries three significant disadvantages including poor yield, unwanted polymerization or conversion to acrylic acid, and difficult regeneration of the Cu+ catalyst.

Tests have shown that enzyme conversion through the use of nitrile hydratase (extracted from Rhodococcus) although used less frequently, yields higher purity acrylamide. TOKU-E researchers have spent considerable time in optimizing this method as well has downstream purification to increase both yield and purity of the end product. Tests show acrylamide obtained through this production method is 99.9% pure.

Ionic impurities as well as acrylic acid (the main impurity in acrylamide) can have significant effects on the performance of the PAGE gel formed since the voltage across the gel is affected by the ionic charge of the gel and usage buffers. Thus, 99.9% pure acrylamide leads to ultra-low turbidity.

TOKU-E has been using this ultra-pure grade internally and is proud to finally be able to scale it up and offer it in bulk quantities to its bulk and retail customers. As a biotechnology chemical supplier, TOKU-E understands toxic properties associated with acrylamide and thus custom packs it in a custom-built production facility designed for custom packaging flexibility.

About TOKU-E:
TOKU-E specializes in the manufacturing of ultra-pure antimicrobials and fine chemicals for use in life science research. The broad range of antimicrobials produced are primarily designed for gene selection, cell culture, microbiology, anti-mycoplasma, diagnostic applications.


Peter Hinrichs, United States
Phone: 360-734-1789
Fax: 360-734-0798

Moez Ismail, Europe
Phone: +31 (0)10 2232 774
Fax: +31 (0)10 2236 212


TOKU-E, press release, 2012-10-15.




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