{"id":78110,"date":"2020-09-01T07:38:33","date_gmt":"2020-09-01T05:38:33","guid":{"rendered":"https:\/\/renewable-carbon.eu\/news\/?p=78110"},"modified":"2020-08-27T14:58:22","modified_gmt":"2020-08-27T12:58:22","slug":"designed-bacteria-produce-coral-antibiotic","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/designed-bacteria-produce-coral-antibiotic\/","title":{"rendered":"Designed bacteria produce coral-antibiotic"},"content":{"rendered":"
\"csm_200817_Korallen_TB_3522_2100_01_85b4da92e6\"
Horn corals of the species Antillogorgia elisabethae<\/em> produce antibiotic natural substances. A research team at TUM has successfully produced one of these substances in the laboratory. Image: Thomas Br\u00fcck \/ TUM<\/figcaption><\/figure>\n

Corals growing on the reefs of the Bahamas produce an active agent that kills multi-resistant tuberculosis bacteria. Scientists at the Technical University of Munich (TUM) have managed to produce the antibiotic biotechnologically in the laboratory \u2013 fast, cost-efficient and sustainably.<\/strong><\/p>\n

Thomas Br\u00fcck saw the sea whip Antillogorgia elisabethae<\/em> for the first time 17 years ago while diving on a research trip to the Bahamas. He still remembers this encounter vividly, which took place 18 meters below the water\u2019s surface: \u201cTheir polyp-covered, violet branchlets moved gently in the current. A fascinating living organism!\u201d As it also contains various biologically active compounds, the biochemist since then has studied the natural product biosynthesis of this soft coral.<\/p>\n

Sea whips are protected; despite this, their existence is in danger. The collection and sale of dried corals is a lucrative business, as these contain various active agents, including an anti-inflammatory molecule called pseudopterosin, which is used in the cosmetics industry for years.<\/p>\n

\u201cCoral reefs fix and store the greenhouse gas carbon dioxide and are biodiversity hotspots. If we want to protect the world\u2019s reefs, we have to generate such biologically active natural products, via sustainable processes,\u201d says Br\u00fcck.<\/p>\n

Natural antibiotic from the biotechnological laboratory<\/h3>\n

Together with his team at the Werner Siemens Chair of Synthetic Biotechnology, he has now managed for the first time to produce one of the sea whip\u2019s active agents in the laboratory \u2013 without the need for a single reef inhabitant. The molecule \u201cerogorgiaene\u201d is an antibiotic. Initial bioactivity tests show, that it is suitable for fighting multi-resistant tuberculosis pathogens.<\/p>\n

Previously, a use of the active agent was almost unthinkable: The sea whip contains only extremely small quantities of erogorgiaene and is additionally protected \u2013 using it as a raw material source would be neither financially feasible nor ecologically responsible. Although production via conventional chemical synthesis is possible, it is complex and associated with toxic waste. A kilo of the active agent would cost around EUR 21,000.<\/p>\n

Sustainable biotechnology reduces the production costs<\/h3>\n

\u201cHowever, with biotechnological methods, a consolidated erogorgiaene production is feasible, in a more environmentally friendly manner and much cheaper. With this method, the production costs per kilo would only be around EUR 9,000,\u201d emphasizes Br\u00fcck.<\/p>\n

The new method, which he has developed together with colleagues from Berlin, Canada, and Australia, consists of only two steps: The main work is done by genetically optimized bacteria that feed on glycerin \u2013 a residual substance from biodiesel production.<\/p>\n

The bacteria generate a molecule, that can then be converted into the desired active agent using a highly selective enzymatic step. No waste is produced in the process, as all ancillary products can be reused in a circular manner. A patent has been filed for the innovative production method.<\/p>\n

Bioactive product development along the lines of nature<\/h3>\n

\u201cThe new technology platform for the production of bioactive natural products via biotechnological methodologies complies with all 12 criteria of Green Chemistry,\u201d says Thomas Br\u00fcck. \u201cIn addition, it fulfills four of the UN Sustainability Goals: a healthy life for all, combating climate change and its effects, preservation and sustainable use of the oceans and maritime resources, and preservation of life on land.\u201d<\/p>\n

The research team is now working on the biotechnological production of another coral active agent: Using nature as a model, the molecule erogorgiaene is to be converted into the active agent pseudopteropsin in the laboratory.<\/p>\n

Medical professionals are placing great hope on the latter: Clinical studies have shown that pseudopteropsin inhibits inflammations thanks to a new mechanism of action. Thus, it is a potential therapeutic candidate to control excessive inflammatory reactions, for example in the case of viral infections, such as Covid-19, or during age-related chronic inflammations.<\/p>\n

 <\/p>\n

Publications<\/h3>\n

Marion Ringel, Markus Reinbold, Max Hirte, Martina Haack, Claudia Huber, Wolfgang Eisenreich, Mahmoud A. Masri, Gerhard Schenk, Luke W. Guddat, Bernhard Loll, Russell Kerr, Daniel Garbe und Thomas Br\u00fcck:
\nTowards a sustainable generation of pseudopterosin-type bioactives
\nGreen Chemistry, July 20, 2020 \u2013 DOI: 10.1039\/D0GC01697G<\/a><\/p>\n

 <\/p>\n

More information<\/h3>\n

The research was supported by the Federal Ministry of Education and Research (BMBF) in the project \u201cOptimized microbial conversion of biomass residues for sustainable production of high value diterpene bio-actives\u201d (OMCBP) as well as by the Werner Siemens Foundation. In addition to the work groups of Prof. Thomas Br\u00fcck and Prof. Wolfgang Eisenreich at the Technical University of Munich, teams of Prof. Russel G. Kerr, University of Prince Edward Island (Canada), Dr. Bernhard Loll, Freie Universit\u00e4t Berlin (Germany), and Prof. Gary Schenk, University of Queensland (Australia) were involved in the research work.<\/p>\n","protected":false},"excerpt":{"rendered":"

Corals growing on the reefs of the Bahamas produce an active agent that kills multi-resistant tuberculosis bacteria. Scientists at the Technical University of Munich (TUM) have managed to produce the antibiotic biotechnologically in the laboratory \u2013 fast, cost-efficient and sustainably. Thomas Br\u00fcck saw the sea whip Antillogorgia elisabethae for the first time 17 years ago […]<\/p>\n","protected":false},"author":59,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","nova_meta_subtitle":"","footnotes":""},"categories":[5572],"tags":[5796,12042],"supplier":[731,263,15117,1299],"class_list":["post-78110","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-biotechnology","tag-pharmaceuticals","supplier-freie-universitaet-berlin","supplier-technische-universitaet-muenchen","supplier-university-of-prince-edward-island","supplier-university-of-queensland-australien"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/78110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=78110"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/78110\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=78110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=78110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=78110"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=78110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}