{"id":77633,"date":"2020-08-17T06:59:05","date_gmt":"2020-08-17T04:59:05","guid":{"rendered":"https:\/\/renewable-carbon.eu\/news\/?p=77633"},"modified":"2020-08-14T16:12:06","modified_gmt":"2020-08-14T14:12:06","slug":"researchers-solve-a-long-standing-problem-in-organic-chemistry","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/researchers-solve-a-long-standing-problem-in-organic-chemistry\/","title":{"rendered":"Researchers solve a long-standing problem in organic chemistry"},"content":{"rendered":"

They occur in nature, are reactive and play a role in many biological processes: polyenes. It is no wonder that chemists have for a long time been interested in efficiently constructing these compounds \u2013 not least in order to be able to use them for future biomedical applications. However, such designs are currently neither simple nor inexpensive and present organic chemists with major challenges. Scientists at the University of M\u00fcnster headed by Prof. Ryan Gilmour have now found a bio-inspired solution to the problem: They succeeded in constructing complex polyenes such as retinoic acid from simple, geometrically well-defined alkene building blocks. To do this, the scientists used small molecules as “antennas” which they excited with light, thereby enabling difficult chemical reactions to proceed via a process known as \u201cEnergy Transfer Catalysis\u201d.<\/strong><\/p>\n

\"Light-driven
Light-driven flip of alkene geometry
\u00a9 Ryan Gilmour<\/figcaption><\/figure>\n

“The process provides us with a light-driven, operationally simple solution to a conundrum that has occupied us for a long time,” says Dr. John J. Molloy, the first author of the study. The new possibility of forming complex polyenes could facilitate the exploration of these bioactive materials for drug discovery. The study has been published in the journal “Science”.<\/p>\n

Background and method:<\/h3>\n

The alkenes used by the scientists are structural units that can exist in two non-equivalent geometrical forms. These so-called stereoisomers \u2013 i.e. compounds in which the bonding pattern is the same but which differ in the spatial arrangement of the atoms \u2013 are a valuable source of chemical information in biology and are common structural features in larger complex molecules such as retinal, a vitamin A derivative. Although, alkene geometry plays a pivotal role in function, e.g. regulating the mammalian visual cycle, strategies to access geometrically defined alkene building blocks for iterative synthesis are conspicuously underdeveloped. Although many methods exist to access each isomer independently, they are often plagued by poor selectivity or require laborious independent synthesis campaigns.<\/p>\n

Much as plants convert light to energy, the researchers harnessed small, inexpensive organic molecules under irradiation to \u201cflip\u201d common alkene building blocks into the more challenging form. This process is termed \u201cenergy transfer catalysis\u201d.<\/p>\n

Since these materials are functionalised at both sites, they could be iteratively extended to construct complex bioactive polyenes such as retinoic acid, which may exist in multiple forms by virtue of alkene stereoisomerism. The M\u00fcnster team demonstrated the power of their method in short, stereocontrolled syntheses of two retinoic acid-based drugs Isotretinoin and Alitretinoin.<\/p>\n

The new method combines the importance of carbonyl chemistry in biosynthesis with the versatility of organoboron motifs in contemporary organic chemistry. \u201cThis article is dedicated to Prof. Duilio Arigoni, who recently passed away. He was a pioneer in bio-organic chemistry with whom I had the pleasure to work with in Z\u00fcrich years ago and he often highlighted the urgency of this problem. This innovative solution is testimony to the hard work, innovation a dedication of a very talented group of highly motivated co-workers and I would like to take this opportunity to acknowledge them,\u201d says Ryan Gilmour.<\/p>\n

Funding:<\/h3>\n

The study received financial support by the University of M\u00fcnster, the Collaborative Research Center (SFB) 858 \u201cSynergistic Effects in Chemistry \u2013 From Additivity towards Cooperativity\u201d funded by the German Research Foundation, the Alexander von Humboldt Foundation and the \u201cVerband der Chemischen Industrie\u201d in Germany.<\/p>\n

Original publication:<\/h3>\n

J. J. Molloy & Michael Sch\u00e4fer et al. (2020). Boron-enabled geometric isomerization of alkenes via selective energy-transfer catalysis. Science; DOI:10.1126\/science.abb7235<\/p>\n","protected":false},"excerpt":{"rendered":"

They occur in nature, are reactive and play a role in many biological processes: polyenes. It is no wonder that chemists have for a long time been interested in efficiently constructing these compounds \u2013 not least in order to be able to use them for future biomedical applications. However, such designs are currently neither simple […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","nova_meta_subtitle":"","footnotes":""},"categories":[5572],"tags":[15836,11592],"supplier":[292],"class_list":["post-77633","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-biomedicine","tag-polymers","supplier-universitaet-muenster"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/77633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=77633"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/77633\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=77633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=77633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=77633"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=77633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}