{"id":57351,"date":"2018-10-16T06:45:06","date_gmt":"2018-10-16T04:45:06","guid":{"rendered":"https:\/\/rss.nova-institut.net\/public.php?url=http%3A%2F%2Fwww.innovations-report.com%2Fhtml%2Freports%2Flife-sciences%2Fhighly-organised-process-how-protein-complexes-form-in-the-cell.html"},"modified":"2018-10-14T22:32:37","modified_gmt":"2018-10-14T20:32:37","slug":"highly-organised-process-how-protein-complexes-form-in-the-cell","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/highly-organised-process-how-protein-complexes-form-in-the-cell\/","title":{"rendered":"Highly Organised Process: How Protein Complexes Form in the Cell"},"content":{"rendered":"<p><strong>The formation of protein complexes is a highly organised process that does not begin with the \u201cfinished\u201d proteins. Studies conducted by researchers at the Center for Molecular Biology of Heidelberg University (ZMBH) and the German Cancer Research Center (DKFZ) demonstrate that they already form in a coordinated way when the protein subunits are synthesised. \u201cOur findings fundamentally alter our understanding of how biologically active protein complexes form in the cell,\u201d reports Prof. Dr Bernd Bukau. The results were published in \u201cNature\u201d.<\/strong><\/p>\n<p>Biological processes in cells are driven by thousands of different proteins that are assembled into functionally active protein complexes. The proteins are actually manufactured on the so-called ribosome, which catalyses protein biosynthesis. During the process, amino acids are assembled into chains and folded to form the protein. \u201cUntil now we assumed that the subunits of the protein complexes found one another through diffusion and random encounters,\u201d states Prof. Bukau, who heads the \u201cBiogenesis and Quality Control of Proteins\u201d research group at the ZMBH and the Division of Chaperones and Proteases at the DKFZ.<\/p>\n<p>Experiments conducted by Dr Ayala Shiber on eukaryotes present a different picture, however. The growing protein chains are already bound by other subunits so that protein manufacture and the formation of biologically active protein complexes can be temporally and spatially coordinated. This ensures efficient complex formation, according to Dr Shiber, the lead author of the study. The molecular biologist from Israel and Alexander von Humboldt fellow is a member of Prof. Bukau\u2018s research group and works at the \u201cCellular Surveillance and Damage Response\u201d Collaborative Research Centre (CRC 1036) at Heidelberg University<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The formation of protein complexes is a highly organised process that does not begin with the \u201cfinished\u201d proteins. Studies conducted by researchers at the Center for Molecular Biology of Heidelberg University (ZMBH) and the German Cancer Research Center (DKFZ) demonstrate that they already form in a coordinated way when the protein subunits are synthesised. \u201cOur [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","nova_meta_subtitle":"","footnotes":""},"categories":[5572],"tags":[12377,12981],"supplier":[5035,5956],"class_list":["post-57351","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-biosynthesis","tag-protein","supplier-deutsches-krebsforschungszentrum-dkfz","supplier-ruprecht-karls-universitat-heidelberg"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/57351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=57351"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/57351\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=57351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=57351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=57351"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=57351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}