{"id":51902,"date":"2018-04-20T06:50:00","date_gmt":"2018-04-20T04:50:00","guid":{"rendered":"https:\/\/rss.nova-institut.net\/public.php?url=http%3A%2F%2Fwww.cell.com%2Ftrends%2Fbiotechnology%2Ffulltext%2FS0167-7799%2818%2930094-5%3Frss%3Dyes"},"modified":"2018-04-17T10:05:49","modified_gmt":"2018-04-17T08:05:49","slug":"bio-based-strategies-for-producing-glycosaminoglycans-and-their-oligosaccharides","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/bio-based-strategies-for-producing-glycosaminoglycans-and-their-oligosaccharides\/","title":{"rendered":"Bio-Based Strategies for Producing Glycosaminoglycans and Their Oligosaccharides"},"content":{"rendered":"<p>Various microbial cell factories have been constructed to produce unsulfated GAGs such as hyaluronan, heparosan, and chondroitin.<\/p>\n<p>Different categories of GAG hydrolases and lyases have been characterized and applied for producing GAG oligosaccharides.<\/p>\n<p>Novel microbial\/enzymatic strategies have been developed for the biosynthesis of GAGs and their oligosaccharides from inexpensive sugars.<br \/>\nGlycosaminoglycans (GAGs) and their oligosaccharides have attracted extensive attention because of their wide applications in cosmetics, health, and clinical treatment of, for example, thrombus, osteoarthritis, rheumatism, and cancer. Compared to conventional preparation approaches, bio-based strategies for producing GAGs and their oligosaccharides are more promising because they avoid cross-infection of human and animal diseases, use green production processes, and can precisely control the degree of sulfation and molecular weight. This review summarizes recently developed bio-based strategies for producing GAGs, highlighting in particular enzymatic, metabolic engineering, and synthetic biology strategies. Directions and prospects for near-future research are also outlined and discussed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Various microbial cell factories have been constructed to produce unsulfated GAGs such as hyaluronan, heparosan, and chondroitin. Different categories of GAG hydrolases and lyases have been characterized and applied for producing GAG oligosaccharides. Novel microbial\/enzymatic strategies have been developed for the biosynthesis of GAGs and their oligosaccharides from inexpensive sugars. Glycosaminoglycans (GAGs) and their oligosaccharides [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","nova_meta_subtitle":"","footnotes":""},"categories":[5572],"tags":[13056,12377],"supplier":[11310],"class_list":["post-51902","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-biological","tag-biosynthesis","supplier-cell-magazine"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/51902","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=51902"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/51902\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=51902"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=51902"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=51902"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=51902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}