A new biosynthetic pathway uses E. coli to synthesize acrylate monomers for potential use as anti-fouling agents. The zwitterionic monomer 2-acetylamidoacrylate has the potential to prevent biofouling in virtuallyall anti-biofouling polymer applications. Metabolic engineering first produces serine, which is then converted and dehydrated to 2-acetylamidoacrylate, which is then polymerized and hydrolyzed into a zwitterionic material.
\nLower Cost, No Toxicity<\/p>\n
Current solutions to biofouling suffer from high cost, low efficacy, and cause environmental damage. Using synthetic zwitterionic materials to make antifouling coatings requires complicated chemical synthesis and is cost-prohibitive for large-scale applications. Acrylate polymers are expensive to synthesize in bulk, and biocides are toxic to marine life. This technology produces zwitterionic acrylate monomers using a designed biological pathway in E. coli. The biosynthetic process effectively generates molecules with a unique combination of C\/H\/O\/N inaccessible by conventional chemical synthesis, at lower cost than current methods and with no toxicity.<\/p>\n
BENEFITS AND FEATURES:<\/p>\n
Biosynthetic process in Escherichia coli (E. coli)
\nZwitterionic acrylate monomers of varying carbon length
\nLower cost than current zwitterionic materials
\nFunctionally superior
\nNon-toxic
\nExpected to prevent adhesion<\/p>\n
APPLICATIONS:<\/p>\n
Antifouling coatings industry
\nMarine coatings – shipping and\/or naval applications
\nImplanted medical devices
\nHousehold plumbing<\/p>\n
PHASE OF DEVELOPMENT:<\/p>\n
Concept. Initial pathway assembled in E. coli; 2\u2011acetylamidoacrylate monomer synthesized at 1 g\/L in shake flask experiments and polymerization of zwitterionic monomer has been demonstrated. Antifouling properties need to be demonstrated.<\/p>\n","protected":false},"excerpt":{"rendered":"
A new biosynthetic pathway uses E. coli to synthesize acrylate monomers for potential use as anti-fouling agents. The zwitterionic monomer 2-acetylamidoacrylate has the potential to prevent biofouling in virtuallyall anti-biofouling polymer applications. Metabolic engineering first produces serine, which is then converted and dehydrated to 2-acetylamidoacrylate, which is then polymerized and hydrolyzed into a zwitterionic material. […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","nova_meta_subtitle":"","footnotes":""},"categories":[5572],"tags":[13957],"supplier":[2640],"class_list":["post-47711","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-biosynthetic","supplier-university-of-minnesota"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/47711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=47711"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/47711\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=47711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=47711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=47711"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=47711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}