The last 70 years have been transformational for the Indian biotech industry, mirroring the nation\u2019s own rapidly advancing economy and rising global status. We have successfully leveraged recombinant DNA technology to deliver biopharmaceuticals, vaccines, genetically engineered crops and enzymes. In doing so, we have created a notable bio-economy valued at $35 billion.<\/p>\n
We have embraced cutting-edge technologies, built global scale manufacturing capacities, and benchmarked our systems and strategies to global best practices. Currently, India is among the top 12 biotechnology destinations in the world and ranks third in the Asia-Pacific region. While our immediate goal is to build a $100 billion bio-economy in India by 2025, in the next 30 years, India aspires to become a biotechnology hot spot reputed for its high-value, low-cost innovations in bio-therapeutics including personalised and precision medicine, advanced enzyme technologies, GM crops and bioinformatics.<\/p>\n
The success of India\u2019s biotechnology industry can be traced to the pioneering spirit of entrepreneurs who leveraged a nascent technology and India\u2019s cost-effective scientific talent pool to bring affordable innovations to the market. Its evolution over the decades mirrored the country\u2019s growing confidence in life sciences. While the 1980s were the decade of enzymes, the next decade saw vaccines gaining prominence as a business segment. The emergence of genomics research companies in the 2000s was followed by Novel biologics and biosimilars making an impact from 2010 onwards.<\/p>\n
I started Biocon as India\u2019s first biotech enterprise in 1978 in a garage in Bengaluru to manufacture industrial enzymes for food and textile industries around the world. The initial years were tough as I encountered market scepticism, funding challenges, infrastructural hurdles, manpower issues and government apathy. I persevered because I believed biotechnology was the technology of the future with the potential to deliver transformational change.<\/p>\n
By the mid-1980s, Biocon had evolved as the largest enzymes company of India pursuing an R&D-led biotech business. As few more biotechnology-based companies started coming up, it caught the attention of the government and, in 1986, the Department of Biotechnology (DBT) was established. I was privileged to be invited to be a part of the DBT\u2019s Task Force, which helped articulate the regulatory framework for the industry. Recombinant technologies were at the fulcrum of regulations covering vaccines, genetically modified crops and biopharmaceuticals.<\/p>\n
Biocon\u2019s stock market debut in 2004, as the first biotech company in India to go public, commanded a premium valuation. It led to the development of a biocluster in Bengaluru, attracting a number of large and small biotech companies. These included Strand Genomics, a bioinformatics company; Gangagen, a phage-based antibiotic company; Reametrix, a whole blood-based diagnostics instrumentation company; Syngene, which spearheaded research services; and Bio-IT companies like Genotypic Technology, BigTec and Molecular Connections. The cluster also spurred the growth of ancillary biotech companies.<\/p>\n
The disruptive power of Indian biotechnology innovation grabbed the attention of the world in the late 1990s when companies like Shantha Biotechnics, Bharat Biotech, and Serum Institute started producing and supplying vaccines at a fraction of the cost of western drug makers. Today, \u20181 in 3\u2019 children globally are immunised with a \u2018Made in India\u2019 vaccine.<\/p>\n
Having built a strong base of indigenous R&D capabilities and excellent clinical trials and manufacturing infrastructure, the industry started developing biotech-based drugs or biologics. Taking the lead, Biocon introduced India\u2019s indigenously developed recombinant human insulin using a proprietary fermentation technology in 2004 and, along with Wockhardt, was able to break the monopoly of innovators in insulins by offering indigenously manufactured affordable alternatives, thus enhancing access to this life-saving therapy.<\/p>\n
Over the years, Biocon has successfully launched two novel biologics and five biosimilar products aimed at cancer, diabetes and autoimmune diseases, making these advanced therapies available to a large patient population. Today, there are a select few companies such as Dr. Reddy\u2019s Labs, Zydus Cadila, Intas Pharma, Reliance Life Sciences, Lupin, etc., which are active in the area of complex biologics\/biosimilars. The biotechnology sector is evolving fast and it promises to transform healthcare, agriculture and environmental management, leading to the dawn of the \u2018Biotechnology Age\u2019.<\/p>\n
By 2030, the Indian bio-economy sector is expected to attain a size of $200 billion. I foresee the intelligent use of data to transform global health. India\u2019s highly developed software skills offer a unique Bio-IT opportunity to mine, analyse and interpret data and create algorithms that can match therapies with the diagnosis. There is also considerable excitement over the promise of targeted genome editing technologies like CRISPR CAS9, which can potentially prevent several diseases, including some cancers, and prevent specific genetic anomalies from being passed on to future generations.<\/p>\n
I believe, by 2050, cancer will become manageable through advances in the field of immuno-oncology, which works by stimulating an immune response against malignant tumours, thus replacing the need for chemotherapy and radiotherapy.<\/p>\n
Biotechnology in agriculture and farming has the potential to address numerous challenges associated with food security in India. Just as the commercial cultivation of genetically modified cotton in India, starting 2002, helped convert the country from a net importer to a net exporter of cotton, selective propagation of genes that improve yields and are resistant to pests, flooding and drought, could make food cheaper, more nutritious and abundant.<\/p>\n
Bioremediation techniques, which offer a cheaper alternative to conventional cleaning technologies, can be used to address the impending global crisis in the area of water and energy. Application of technologies like the ones being developed by Sea6 Energy, will help harness the potential of the oceans to provide solutions in energy, agriculture and feed, thus helping restore the ecological balance.<\/p>\n","protected":false},"excerpt":{"rendered":"
The last 70 years have been transformational for the Indian biotech industry, mirroring the nation\u2019s own rapidly advancing economy and rising global status. We have successfully leveraged recombinant DNA technology to deliver biopharmaceuticals, vaccines, genetically engineered crops and enzymes. In doing so, we have created a notable bio-economy valued at $35 billion. We have embraced […]<\/p>\n","protected":false},"author":59,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","nova_meta_subtitle":"","footnotes":""},"categories":[5572],"tags":[5838,5796],"supplier":[7304],"class_list":["post-45492","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-bioeconomy","tag-biotechnology","supplier-biocon"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/45492","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=45492"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/45492\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=45492"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=45492"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=45492"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=45492"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}