{"id":40052,"date":"2017-01-25T07:29:28","date_gmt":"2017-01-25T06:29:28","guid":{"rendered":"https:\/\/renewable-carbon.eu\/news\/?p=40052"},"modified":"2017-01-23T12:05:17","modified_gmt":"2017-01-23T11:05:17","slug":"wyss-institute-patching-a-gap-in-wound-care","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/wyss-institute-patching-a-gap-in-wound-care\/","title":{"rendered":"Wyss Institute: Patching a gap in wound care"},"content":{"rendered":"

Chitosan, a biomaterial derived from the chitin shells of crustaceans and insects, has already been developed by scientists at Harvard\u2019s Wyss Institute for Biologically Inspired Engineering into an environmentally-friendly and fully biodegradable substitute for plastic. It is only natural that the team, led by Wyss Institute Founding Director Donald Ingber, has also become interested in extending chitosan\u2019s usefulness into the clinical realm.<\/strong><\/p>\n

\u201cWhat\u2019s good for the environment is also good for us,\u201d said Javier Fernandez, who first developed a chitosan bioplastic called \u2018Shrilk\u2019 with Ingber back in 2014<\/a>.<\/p>\n

\"biofilm\"
A Wyss Institute team has leveraged a commercially-available enzyme called transglutaminase to directly bond chitosan biomaterial (such as liquid chitosan pictured here) to bodily tissue in a variety of forms including sheet, spray, and foam application. Credit: Wyss Institute at Harvard University<\/figcaption><\/figure>\n

Now Ingber and Fernandez have unveiled a new study<\/a> in the journal Tissue Engineering<\/em> that demonstrates biodegradable chitosan bioplastics can be used to bond bodily tissues to repair wounds or even to hold implanted medical devices in place. As chitosan is already approved for clinical use and it has antimicrobial properties, the approach could one day be utilized to immediately seal tissue tears or other serious injuries, preventing infection from setting in before a patient can be moved to a hospital for more in-depth care.<\/p>\n

\u201cThis work really spans the entire mission of the Wyss, as we have developed a biomaterial that could be used in sustainable consumer products and packaging or, as we now show, be adapted for clinical uses,\u201d said Fernandez, Ph.D., the first author on the new study, who is a former Wyss Institute Postdoctoral Fellow and is currently an Assistant Professor at Singapore University of Technology and Design. \u201cThe material is non-toxic and biodegradable, leaving behind no trace once it has served its purpose.\u201d<\/p>\n

To adapt chitosan to seal wounds and surgical incisions, Ingber and Fernandez searched for a way to quickly and tightly bond chitosan materials to living tissues. They zeroed in on transglutaminase (TG), a naturally occurring enzyme found in the body \u2013 where it keeps skin strong and strengthens blood clots \u2013 that has also been adopted to bond proteins together during commercial food processing.<\/p>\n

\"SNAP-112248-0006-Listing-Image\"
In this image of chitosan foam bonded to a one-centimeter-long defect in explanted porcine muscle, the foam is so well adhered to the muscle that it is notably difficult to distinguish the transition between chitosan foam and native tissue. Credit: Wyss Institute at Harvard University<\/figcaption><\/figure>\n

\u201cAs we started thinking about going in vivo, we faced the challenge of how to adhere chitosan to living tissues,\u201d said Ingber, M.D., Ph.D., who is senior author on the new study and in addition to directing the Wyss Institute is Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children\u2019s Hospital as well as Professor of Bioengineering at Harvard\u2019s John A. Paulson School of Engineering an Applied Sciences. \u201cWe explored using different formulations of transglutaminase to bond various forms of chitosan materials, including sheets, foams and sprays, to many different types of tissues.\u201d<\/p>\n

A sheet of chitosan may be applied with a transglutaminase powder to patch wounds, as the team demonstrated using an ex vivo porcine intestine with a large hole in it. A pressure test revealed that the chitosan patch was even stronger than the native intestinal tissue.<\/p>\n

For the spray, a stream of liquid chitosan and liquid transglutaminase combine during application to quickly bond chitosan to tissue and close wounds. The team used this approach to seal a porcine lung that had sustained a puncture wound while it was cyclically insufflated with air to mimic inspiration and expiration. The spray application could also be useful for covering large areas of vulnerable tissue, like might be found on someone whose skin had sustained serious burns.<\/p>\n

To treat even larger and more traumatic wounds like those that might occur on the battlefield or during a motor vehicle accident, Ingber and Fernandez formulated a chitosan foam that could potentially be used to fill and seal larger wound cavities until a patient can be transported to a hospital for surgical intervention.<\/p>\n

The team\u2019s findings also suggest that their approach could be tailored to bond inorganic surfaces \u2013 which make up crucial components of many different kinds of biomedical implants and microfluidic devices \u2013 to tissue or chitosan.<\/p>\n

\u201cRight now our approach is very general, but we could theoretically take this concept and adapt it into almost any form imaginable for a broad number of possible uses,\u201d said Fernandez.<\/p>\n

Looking ahead, the team hopes to develop an array of specific applications through collaboration with clinical partners.<\/p>\n

Additional co-authors on the study include Wyss Institute researchers Suneil Seetharam, Christopher Ding, and Edward Doherty.<\/p>\n

 <\/p>\n

About the Wyss Institute<\/h3>\n

The Wyss Institute for Biologically Inspired Engineering at Harvard University uses Nature\u2019s design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world. Wyss researchers are developing innovative new engineering solutions for healthcare, energy, architecture, robotics, and manufacturing that are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and formation of new startups. The Wyss Institute creates transformative technological breakthroughs by engaging in high risk research, and crosses disciplinary and institutional barriers, working as an alliance that includes Harvard\u2019s Schools of Medicine, Engineering, Arts & Sciences and Design, and in partnership with Beth Israel Deaconess Medical Center, Brigham and Women\u2019s Hospital, Boston Children\u2019s Hospital, Dana\u2013Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Boston University, Tufts University, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, University of Zurich and Massachusetts Institute of Technology.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chitosan, a biomaterial derived from the chitin shells of crustaceans and insects, has already been developed by scientists at Harvard\u2019s Wyss Institute for Biologically Inspired Engineering into an environmentally-friendly and fully biodegradable substitute for plastic. It is only natural that the team, led by Wyss Institute Founding Director Donald Ingber, has also become interested in […]<\/p>\n","protected":false},"author":59,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","nova_meta_subtitle":"","footnotes":""},"categories":[5572],"tags":[11270,5935,6026],"supplier":[13016],"class_list":["post-40052","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-biodegradability","tag-bioplastic","tag-biopolymers","supplier-wyss-institute-at-harvard"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/40052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=40052"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/40052\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=40052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=40052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=40052"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=40052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}