WASILLA \u2014 The results of their tests on rodent and pig tissue were published in Colloids and Surfaces B: Biointerfaces, a peer-reviewed scientific journal that focuses on bioengineered materials, in October.<\/p>\n
Surgical sealants are mainly used to stop bleeding in wounds from surgical cuts during a procedure. The first sealants were invented in 1909, and made from human plasma and an enzyme derived from cattle. But according to a rehash of the technology\u2019s history, (\u201cEvolution of hemostatic agents in surgical practice,\u201d Indian Journal of Urology, 2010), they came with steep drawbacks. Patients\u2019 immune systems often reacted poorly to the material. And at the time, human plasma screening was inadequate to prevent transmission of blood-borne viruses to patients. This led to new viral infections.<\/p>\n
Interest in the material did not revive until the 1960s, when researchers began addressing these problems. Adoption of surgical sealants in clinical practice in Europe and Asia increased through the 1980s, but their use in the United States didn\u2019t begin until the 1990s.<\/p>\n
American surgeons typically made their own preparations of surgical sealant until 1998, when the first commercially-produced sealant won FDA approval.<\/p>\n
Originally used primarily in cardiovascular surgeries, sealants have been applied to an increasing number of procedures, with spinal surgeries topping the list. Market research projects the market for surgical sealants will be worth $2.64 billion by 2020.<\/p>\n
Today, sealants can be an important tool in the battle against incidental bleeding during surgery, leading to less overall blood loss and a lesser need for transfusions, and reducing scarring and risk of surgery-related infection.<\/p>\n
But sealants continue to have several drawbacks, and that\u2019s put biomedical companies in a race to develop a more high-performance sealant that stays sticky when wet, and biodegrades as the body heals without causing inflammation.<\/p>\n
Biomaterials, often from animal-derived gelatins, have risen to the challenge. But they frequently need to be heated first before they can be applied.<\/p>\n
The recent study at Tsukuba University shows cold-water fish might be the answer.<\/p>\n
\u201cThe gelatin of cold-water fish in particular (e.g. cod, hake, Alaska pollock and salmon) shows higher fluidity compared with porcine- or bovine-derived gelatin,\u201d the study\u2019s authors wrote. That made it an attractive pick for use in surgical sealant research and development.<\/p>\n
The Alaska pollock used in the study was acquired from an Osaka gelatin manufacturing plant, and prepared in a chemical treatment to give it hydrophobic qualities \u2013 that is, make it water-proof.<\/p>\n
Researchers found that the Alaska pollock-based sealant performed well as an adhesive in wet conditions on their test pig blood vessel tissue. They also found in test applications to subcutaneous mouse tissue that it performed well as an adhesive and biodegraded fully within eight weeks without causing inflammation.<\/p>\n
And because it\u2019s derived from cold-water fish, it didn\u2019t need the heat treatment to be ready to go.<\/p>\n
While gelatins have been a commonly used and important material for a wide variety of applications, including in modern medicine, the first published exploration of fish gelatin for general biomedical uses did not occur until 2013 (\u201cThermal and hydrolytic degradation of electrospun fish gelatin membranes,\u201d Polymer Testing.)<\/p>\n
Other non-food materials made from Alaska seafood has mainly been limited to explorations of its use as a biofuel. The Alaska Biodiesel Project estimates 8 million gallons of waste fish oil is produced in the total by the Alaska seafood industry each year. Alaska Waste, a waste products and recycling company, opened the first fish-based commercial biodiesel plant in 2010.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
WASILLA \u2014 The results of their tests on rodent and pig tissue were published in Colloids and Surfaces B: Biointerfaces, a peer-reviewed scientific journal that focuses on bioengineered materials, in October. Surgical sealants are mainly used to stop bleeding in wounds from surgical cuts during a procedure. The first sealants were invented in 1909, and […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","nova_meta_subtitle":"","footnotes":""},"categories":[5572],"tags":[8793,5817],"supplier":[12823,12822,2713],"class_list":["post-38840","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-biomaterials","tag-research","supplier-alaska-waste","supplier-university-of-tsukuba","supplier-us-food-and-drug-administration-fda"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/38840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=38840"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/38840\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=38840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=38840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=38840"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=38840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}