{"id":19482,"date":"2014-03-07T03:12:34","date_gmt":"2014-03-07T01:12:34","guid":{"rendered":"https:\/\/renewable-carbon.eu\/news\/?p=19482"},"modified":"2014-03-06T15:27:41","modified_gmt":"2014-03-06T13:27:41","slug":"silk-based-surgical-implants-offer-better-way-repair-broken-bones","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/silk-based-surgical-implants-offer-better-way-repair-broken-bones\/","title":{"rendered":"Silk-Based Surgical Implants Could Offer a Better Way to Repair Broken Bones"},"content":{"rendered":"
\"silkscrewscropped\"
Silk screws offer a promising new way to repair bone fractures.<\/figcaption><\/figure>\n

MEDFORD\/SOMERVILLE, MASS. and BOSTON — When a person suffers a broken bone, treatment calls for the surgeon to insert screws and plates to help bond the broken sections and enable the fracture to heal. These \u201cfixation devices\u201d are usually made of metal alloys.<\/strong><\/p>\n

But metal devices may have disadvantages: Because they are stiff and unyielding, they can cause stress to underlying bone. They also pose an increased risk of infection and poor wound healing. In some cases, the metal implants must be removed following fracture healing, necessitating a second surgery. Resorbable fixation devices, made of synthetic polymers, avoid some of these problems but may pose a risk of inflammatory reactions and are difficult to implant.<\/p>\n

Now, using pure silk protein derived from silkworm cocoons, a team of investigators from Tufts University School of Engineering and Beth Israel Deaconess Medical Center (BIDMC) has developed surgical plates and screws (shown above) that may not only offer improved bone remodeling following injury, but importantly, can also be absorbed by the body over time, eliminating the need for surgical removal of the devices.<\/p>\n

The findings, demonstrated in vitro and in a rodent model, are described in the March 4 issue of Nature Communications.<\/p>\n

\u201cUnlike metal, the composition of silk protein may be similar to bone composition,\u201d says co-senior author Samuel Lin, MD, of the Division of Plastic and Reconstructive Surgery at BIDMC and Associate Professor of Surgery at Harvard Medical School. \u201cSilk materials are extremely robust. They maintain structural stability under very high temperatures and withstand other extreme conditions, and they can be readily sterilized.\u201d<\/p>\n

Collaborating with Lin were co-senior author and Tufts chair of biomedical engineering David Kaplan, PhD, a leader in the use of silk for biomedical applications, and a team of biomedical and mechanical engineers.<\/p>\n

\u201cOne of the other big advantages of silk is that it can stabilize and deliver bioactive components, so that plates and screws made of silk could actually deliver antibiotics to prevent infection, pharmaceuticals to enhance bone regrowth and other therapeutics to support healing,\u201d says Kaplan.<\/p>\n

Kaplan and his team have previously developed silk-based sponges, fibers and foams for use in the operating room and in clinical settings. But until now, silk hadn\u2019t been used in the development of a solid medical device for fracture fixation.<\/p>\n

The Tufts researchers used silk protein obtained from Bombyx mori (B. mori) silkworm cocoons to form the surgical plates and screws. Produced from the glands of the silkworm, the silk protein is folded in complex ways that give it unique properties of both exceptional strength and versatility.<\/p>\n

To test the new devices, the investigators implanted a total of 28 silk-based screws in six laboratory rats. Insertion of screws was straightforward and assessments were then conducted at four weeks and eight weeks, post-implantation.<\/p>\n

\u201cNo screws failed during implantation,\u201d says Kaplan, explaining that because silk is slow to swell, the new devices maintained their mechanical integrity even when coming into contact with fluids and surrounding tissue during surgery. The outcomes suggest that the use of silk plates and screws can spare patients the complications of removal of metal devices or potential inflammatory hydrolytic products from synthetic polyesters.<\/p>\n

\u201cHaving a resorbable, long-lasting plate and screw system has potentially huge applications,\u201d says Lin. While the initial aim is to use silk-based screws to treat facial injuries, which occur at a rate of several hundred thousand each year, the devices have the potential for the treatment of a variety of different types of bone fractures.<\/p>\n

\u201cBecause the silk screws are inherently radiolucent [not seen on X-ray] it may be easier for the surgeon to see how the fracture is progressing during the post-op period, without the impediment of metal devices,\u201d adds Lin. \u201cAnd having an effective system in which screws and plates \u2018melt away\u2019 once the fracture is healed may be of enormous benefit. We\u2019re extremely excited to continue this work in larger animal models and ultimately in human clinical trials.\u201d<\/p>\n

In addition to Lin, Kaplan and Perrone, coauthors include Tufts University investigators Gary G. Leisk, Tim J. Lo, Jodie E. Moreau, Dylan S. Haas, Bernke J. Papenburg, Ethan B. Golden and Benjamin P. Partlow, and BIDMC investigators Sharon E. Fox and Ahmed M.S. Ibrahim.<\/p>\n

This research was supported by the National Institutes of Health (EB002520).<\/p>\n

\u201cThe Use of Silk-Based Devices for Fracture Fixation,\u201d Gabriel S. Perrone, Gary G. Leisk, Tim J. Lo, Jodie E. Moreau, Dylan S. Haas, Bernke J. Papenburg, Ethan B. Golden, Benjamin P. Partlow, Sharon E. Fox, Ahmed M.S. Ibrahim, Samuel J. Lin, David L. Kaplan, Nature Communications, http:\/\/dx.doi.org\/10.1038\/ncomms4385<\/a>.<\/p>\n

Beth Israel Deaconess Medical Center is a patient care, teaching and research affiliate of Harvard Medical School, and currently ranks third in National Institutes of Health funding among independent hospitals nationwide.<\/p>\n

The BIDMC health care team includes Beth Israel Deaconess Hospital-Milton, Beth Israel Deaconess Hospital-Needham, Beth Israel Deaconess Hospital-Plymouth, Anna Jaques Hospital, Cambridge Health Alliance, Lawrence General Hospital, Signature Health Care, Commonwealth Hematology-Oncology, Beth Israel Deaconess HealthCare, Community Care Alliance, and Atrius Health. BIDMC is also clinically affiliated with the Joslin Diabetes Center and Hebrew Senior Life and is a research partner of Dana-Farber\/Harvard Cancer Center. BIDMC is the official hospital of the Boston Red Sox. For more information, visit www.bidmc.org<\/a>.<\/p>\n

About Tufts University School of Engineering<\/strong><\/em>
\nLocated on Tufts\u2019 Medford\/Somerville campus, the Tufts University School of Engineering offers a rigorous engineering education in a unique environment that blends the intellectual and technological resources of a world-class research university with the strengths of a top-ranked liberal arts college. Close partnerships with Tufts\u2019 excellent undergraduate, graduate and professional schools, coupled with a long tradition of collaboration, provide a strong platform for interdisciplinary education and scholarship. The School of Engineering\u2019s mission is to educate engineers committed to the innovative and ethical application of science and technology in addressing the most pressing societal needs, to develop and nurture twenty-first century leadership qualities in its students, faculty, and alumni, and to create and disseminate transformational new knowledge and technologies that further the well-being and sustainability of society in such cross-cutting areas as human health, environmental sustainability, alternative energy, and the human-technology interface.
\n<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

MEDFORD\/SOMERVILLE, MASS. and BOSTON — When a person suffers a broken bone, treatment calls for the surgeon to insert screws and plates to help bond the broken sections and enable the fracture to heal. These \u201cfixation devices\u201d are usually made of metal alloys. But metal devices may have disadvantages: Because they are stiff and unyielding, […]<\/p>\n","protected":false},"author":59,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","nova_meta_subtitle":"","footnotes":""},"categories":[5572],"tags":[],"supplier":[6671,2212,6333],"class_list":["post-19482","post","type-post","status-publish","format-standard","hentry","category-bio-based","supplier-beth-israel-medical","supplier-biomedical-engineering-tufts-university","supplier-national-institutes-of-health-nih"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/19482","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=19482"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/19482\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=19482"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=19482"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=19482"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=19482"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}