{"id":170540,"date":"2025-11-19T07:20:00","date_gmt":"2025-11-19T06:20:00","guid":{"rendered":"https:\/\/renewable-carbon.eu\/news\/?p=170540"},"modified":"2025-11-13T12:08:50","modified_gmt":"2025-11-13T11:08:50","slug":"recycling-co2-into-bioingredients-towards-synthetic-photo-litho-mixotrophy","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/recycling-co2-into-bioingredients-towards-synthetic-photo-litho-mixotrophy\/","title":{"rendered":"Recycling CO2\u00a0into bioingredients: towards synthetic photo\/litho-mixotrophy"},"content":{"rendered":"\n\n\n

C1 and C2 compounds (e.g., formate, methanol, and acetate) produced through carbon-capture technologies can be converted into food ingredients and bioproducts via biorefineries which are essential for building a carbon-neutral economy.<\/p>\n\n\n

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\u00a9 cell.com<\/figcaption><\/figure><\/div>\n\n\n

Integration of CO2<\/sub>-fixing reactions into heterotrophic synthetic metabolic networks can enhance carbon efficiency; however, current C1\/C2 biomanufacturing platforms remain suboptimal due to the need for aeration and inevitable CO2<\/sub>emissions when regenerating reducing power, NAD(P)H, and ATP via heterotrophic pathways.<\/p>\n\n\n\n

Photo-mixotrophic and litho-mixotrophic systems aim to convert all carbon from C1\/C2 feedstocks into biomass and target products without CO2<\/sub> emissions. In photo-mixotrophic systems, photon energy is converted into intracellular energy and reducing power via photosynthetic pathways, while litho-mixotrophic systems integrate water electrolysis and produce reducing power and energy through aerobic H2<\/sub> oxidation. Both offer solutions for electricity-driven biosynthesis.<\/p>\n\n\n\n

The flexibility and modularity of metabolic pathways facilitate the redesign and reconstruction of heterologous metabolic systems with improved stoichiometric and thermodynamic balances for bioproduction.<\/p>\n\n\n\n

Configuring a balanced metabolic network in vivo<\/em> is essential to achieve optimal mixotrophic production. Synthetic biocomputing\/metabolic control mechanisms can be engineered for precise and stable regulation of genetic and metabolic activities.<\/p>\n\n\n\n

Abstract<\/h3>\n\n\n\n

Advances in carbon capture and gas fermentation technologies enable the sustainable production of one-carbon (C1) and C2 organic molecules, such as formate and acetate, by recycling CO2<\/sub> and organic wastes. Refining C1 and C2 feedstocks into food and other organic ingredients is essential for establishing a carbon-neutral economy. However, current C1\/C2-utilizing microbial refinery platforms have yet to achieve ideal carbon efficiency at industrial scales. We critically review progress in innovating metabolic systems across heterotrophic, photosynthetic, and gas fermentation microbial platforms including CO2<\/sub>-fixing and C1-assimilating pathways. Innovative mixotrophic metabolisms, such as photo-mixotrophic and litho-mixotrophic platforms, as well as autotrophic metabolism in heterotrophic platforms, can revolutionize global carbon cycles and enable a sustainable bioeconomy by recycling carbon waste into bioingredients with unprecedented efficiency.<\/p>\n","protected":false},"excerpt":{"rendered":"

C1 and C2 compounds (e.g., formate, methanol, and acetate) produced through carbon-capture technologies can be converted into food ingredients and bioproducts via biorefineries which are essential for building a carbon-neutral economy. Integration of CO2-fixing reactions into heterotrophic synthetic metabolic networks can enhance carbon efficiency; however, current C1\/C2 biomanufacturing platforms remain suboptimal due to the need […]<\/p>\n","protected":false},"author":59,"featured_media":170559,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","nova_meta_subtitle":"Advances in carbon capture and gas fermentation technologies enable the sustainable production of one-carbon (C1) and C2 organic molecules, such as formate and acetate, by recycling CO2\u00a0and organic wastes","footnotes":""},"categories":[5571],"tags":[10744,12330,16171,20598,10743],"supplier":[3706,1299],"class_list":["post-170540","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-co2-based","tag-carboncapture","tag-ccu","tag-fermentation","tag-photosyntesis","tag-useco2","supplier-australian-research-council-arc","supplier-university-of-queensland-australien"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/170540","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=170540"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/170540\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media\/170559"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=170540"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=170540"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=170540"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=170540"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}