Codexis, Inc., a developer of engineered enzymes for pharmaceutical, biofuel and chemical production, announced today the launch of CodeXyme\u00ae 4 and CodeXyme\u00ae 4X cellulase enzyme packages for use in producing cellulosic sugar for production of biofuels and bio-based chemicals.<\/b><\/p>\n
Codexis\u2019 latest generation of advanced cellulase enzymes, CodeXyme\u00ae 4 for dilute acid pretreatments and CodeXyme\u00ae 4X for hydrothermal pretreatments, exhibits excellent performance, converting up to 85% of available fermentable sugars at high biomass and low enzyme loads. Combined with high strain productivity using the CodeXporter\u00ae enzyme production system, this allows for a cost-in-use that the company believes will be among the lowest available once in full-scale commercial production.<\/p>\n
CodeXyme\u00ae 4 increases performance 10-20% over Codexis\u2019 last generation product, CodeXyme\u00ae 3, measured by the amount of glucan converted into C6 fermentable sugar. For pre-treatments with unconverted xylan, CodeXyme\u00ae 4X maintains the same high C6 sugar activity while having additional C5 sugar conversion.<\/p>\n
“After four years of development using our CodeEvolver\u00ae directed evolution technology platform, we are proud to announce that our high-performing CodeXyme\u00ae cellulases are broadly available for the first time,\u201d said John Nicols, Chief Executive Officer of Codexis. “CodeXyme\u00ae has been tested against other commercially-available cellulases and we have found the performance to be equal or better than alternative enzymes, across various feedstocks and pre-treatment types. We expect CodeXyme\u00ae cellulase to deliver significant cost savings and yield improvements for industrial-scale production of cellulosic sugars.\u201d<\/p>\n
Leading Enzyme Performance<\/b>
During the past several months, CodeXyme\u00ae cellulase has been tested on a variety of feedstocks and pre-treatments, including corn stover, corn cobs, sugarcane bagasse, cane straw, wheat straw and rice straw. In all cases, CodeXyme\u00ae 4 and 4X have been found to convert 75 \u2013 85% of glucan and xylan into C6 and C5 sugars, at 10 \u2013 15g enzyme per kg of glucan. With consistently high sugar conversion, customers are able to convert more sugar into high-value biofuels and bio-based chemicals.<\/p>\n
In independent third-party tests with the National Renewable Energy Laboratory (NREL) in Golden, Colorado and Chemical Engineering Research Consultants in Toronto, Canada, CodeXyme\u00ae cellulase performed comparably or better than other leading enzymes. The studies compared the conversion of glucan to C6 sugars on dilute-acid pre-treated corn stover, using leading commercial enzyme products at their optimal pH and temperature. CodeXyme\u00ae 3 (Codexis\u2019 cellulase enzyme from 2011) was found to convert the same or more glucan at the same enzyme load as competing cellulase packages, and CodeXyme\u00ae 4 fared even better against the latest alternative commercial enzymes.<\/p>\n
Commercial and Manufacturing Plan<\/b>
In September 2012, Codexis established a robust applications capability and has since sold CodeXyme\u00ae 4 and 4X to over a dozen potential partners and customers at lab and pilot scale. CodeXyme\u00ae cellulase has been used successfully to hydrolyze biomass pre-treated with both acid-based and hydrothermal methods, as well as in sequential and simultaneous hydrolysis and fermentation.<\/p>\n
Codexis is scheduled to scale up its novel CodeXyme\u00ae 4X cellulase strain at commercial scale in the second quarter of this year. CodeXyme\u00ae 4X cellulase will also be used in pilot production of bio-based CodeXolTM detergent alcohols in collaboration with Chemtex in Rivalta, Italy by mid-year.<\/p>\n
Upcoming Press Conference at the World Biofuels Conference in Rotterdam, The Netherlands<\/p>\n
Dave Anton, Codexis\u2019 Senior Vice President, Bioindustrials, will discuss CodeXyme\u00ae cellulase today, March 12, 2013 at the World Biofuels Conference in Rotterdam, The Netherlands. The briefing will be held at 1pm (CET) in the Blue Room of the Beurs-World Trade Center.<\/p>\n
About Codexis, Inc.<\/b>
Codexis, Inc. engineers enzymes for pharmaceutical, biofuel and chemical production. Codexis\u2019 proven technology enables scale-up and implementation of biocatalytic solutions to meet customer needs for rapid, cost-effective and sustainable process development \u2013 from research to manufacturing.<\/p>\n
CodeXyme\u00ae, CodeEvolver\u00ae, CodeXporter\u00ae and CodeXol\u2122 are trademarks or registered trademarks of Codexis.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"
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