{"id":156905,"date":"2025-01-23T07:05:00","date_gmt":"2025-01-23T06:05:00","guid":{"rendered":"https:\/\/renewable-carbon.eu\/news\/?p=156905"},"modified":"2025-01-22T14:39:56","modified_gmt":"2025-01-22T13:39:56","slug":"non-conventional-yeasts-promising-cell-factories-for-organic-acid-bioproduction","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/non-conventional-yeasts-promising-cell-factories-for-organic-acid-bioproduction\/","title":{"rendered":"Non-conventional yeasts: promising cell factories for organic acid bioproduction"},"content":{"rendered":"\n\n\n<p><strong>Non-conventional yeasts are ideal hosts for next-generation organic acid production because of their stress tolerance and broad substrate spectrum.<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"325\" height=\"155\" src=\"https:\/\/renewable-carbon.eu\/news\/media\/2025\/01\/images.jpg\" alt=\"\" class=\"wp-image-156907\" srcset=\"https:\/\/renewable-carbon.eu\/news\/media\/2025\/01\/images.jpg 325w, https:\/\/renewable-carbon.eu\/news\/media\/2025\/01\/images-300x143.jpg 300w, https:\/\/renewable-carbon.eu\/news\/media\/2025\/01\/images-150x72.jpg 150w\" sizes=\"auto, (max-width: 325px) 100vw, 325px\" \/><figcaption class=\"wp-element-caption\">\u00a9 Elsevier<\/figcaption><\/figure><\/div>\n\n\n<p>Recent advances in sequencing, omics, and in silico modeling analysis have provided genomic information and genetic toolkits to design and construct robust organic acid producers.<\/p>\n\n\n\n<p>Selecting a microbial host that is well suited to the desired product is an important point for the industrial production of organic acids and can enhance overall process efficiency.<\/p>\n\n\n\n<p>Organic acid production at low pH using acid-tolerant yeasts is financially viable and environmentally beneficial, but this process has not yet been implemented industrially.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Abstract<\/h3>\n\n\n\n<p>Microbial production of organic acids has been hindered by the poor acid tolerance of microorganisms and the high costs of waste salt reprocessing. The robustness of non-conventional microorganisms in an acidic environment makes it possible to produce organic acids at low pH and greatly simplifies downstream processing. In this review we discuss the environmental adaptability features of non-conventional yeasts, as well as the latest developments in genomic engineering strategies that have facilitated metabolic engineering of these strains. We also use selected examples of three-carbon (C3), C4, and C6 organic acids to illustrate the ongoing efforts and challenges of using non-conventional yeasts for organic acid production. This review provides theoretical guidance for the construction of highly robust organic acid producers.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Non-conventional yeasts are ideal hosts for next-generation organic acid production because of their stress tolerance and broad substrate spectrum. Recent advances in sequencing, omics, and in silico modeling analysis have provided genomic information and genetic toolkits to design and construct robust organic acid producers. Selecting a microbial host that is well suited to the desired [&#8230;]<\/p>\n","protected":false},"author":114,"featured_media":156907,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","nova_meta_subtitle":"Microbial production of organic acids has been hindered by the poor acid tolerance of microorganisms and the high costs of waste salt reprocessing","footnotes":""},"categories":[5572],"tags":[5838,10416,14460,13821],"supplier":[7471,5112],"class_list":["post-156905","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bio-based","tag-bioeconomy","tag-circulareconomy","tag-microbial","tag-yeast","supplier-chinese-academy-sciences","supplier-elsevier"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/156905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/114"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=156905"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/156905\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media\/156907"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=156905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=156905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=156905"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=156905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}