{"id":143609,"date":"2024-05-10T07:32:00","date_gmt":"2024-05-10T05:32:00","guid":{"rendered":"https:\/\/renewable-carbon.eu\/news\/?p=143609"},"modified":"2024-05-06T11:45:14","modified_gmt":"2024-05-06T09:45:14","slug":"merck-introduces-new-greener-solvent-cyrene","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/merck-introduces-new-greener-solvent-cyrene\/","title":{"rendered":"Merck Introduces New Greener Solvent, Cyrene\u2122"},"content":{"rendered":"\n\n
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\u00a9 Merck<\/figcaption><\/figure><\/div>\n\n\n

Merck, a leading science and technology company, today launched Cyrene\u2122 \u2014 a sustainable dipolar aprotic solvent, produced in two steps from a renewable cellulose source. The bio-derived alternative was created in response to the need for solvents to meet stricter regulation requirements for both employee safety and environmental sustainability. The new product targets the rising demand for greener alternatives to Dimethylformamide (DMF) and N-Methyl-2-pyrrolidone (NMP).<\/strong><\/p>\n\n\n\n

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\u201cWith a strong focus on green chemistry, Merck is dedicated to providing today\u2019s scientists with innovative solutions to help solve environmental challenges before us,\u201d said Klaus Bischoff, head of Research Solutions, Life Science at Merck<\/strong>. \u201cAs a greener alternative, Cyrene\u2122 solvent allows our customers to improve the safety of their processes and reduce the environmental impact of their research and manufacturing \u2014 without compromising performance.\u201d<\/p>\n<\/blockquote>\n\n\n\n

The Life Science business of Merck uses the 12 Principles of Green Chemistry that were developed and published by thought leaders Paul T. Anastas and John C. Warner in 1991 as a framework for its Green Chemistry practice.<\/p>\n\n\n\n

DMF and NMP are under increasing regulatory restrictions, with both being classified by the European Union\u2019s Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) as substances of very high concern. More recently, according to the European Union, the European Commission added NMP to the restricted substances list known as REACH Annex XVII \u2014 driving the demand for alternatives. Additionally, effective May 2020, consumer products containing more than 0.3 percent NMP will be prohibited in the European Union. Initial studies and testing have found Cyrene\u2122 solvent to be a more sustainable, safer option when compared with DMF and NMP.<\/p>\n\n\n\n

Cyrene\u2122 solvent was developed as a result of a partnership between the University of York\u2019s Green Chemistry Centre of Excellence (GCCE) and Circa Group. Utilizing its expertise in green chemistry, the University of York\u2019s GCCE worked to determine potential applications for the Cyrene\u2122 solvent.<\/p>\n\n\n\n

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\u201cCyrene\u2122 solvent actually outperformed the solvent we currently use for manufacturing graphene \u2014 providing us with both a sustainable and more effective option to traditional solvents,\u201d said James Clark, professor, University of York and director, Green Chemistry Centre of Excellence<\/strong>.<\/p>\n<\/blockquote>\n\n\n\n

Merck also researched alternate uses of Cyrene\u2122 solvent in mild and robust Sonogashira cross-couplings, a common reaction used in medicinal chemistry, with Professor Allan Watson\u2019s group at the University of St. Andrews, United Kingdom.<\/p>\n\n\n\n

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\u201cIt was important for us to find a safer alternative without sacrificing quality,\u201d said Allan Watson, reader in Homogeneous Catalysis, University of St. Andrews.<\/strong> \u201cThrough our research, we found that Cyrene\u2122 solvent features similar physical properties to those of DMF and other dipolar aprotic solvents, while enabling medicinal chemists to execute a more sustainable chemical synthesis.”<\/p>\n<\/blockquote>\n\n\n\n

Cyrene\u2122 solvent was also substituted for DMF in amide couplings \u2014 a fundamental reaction in drug discovery. <\/a>By demonstrating that safer, greener alternatives offer superior performance, Cyrene\u2122 solvent was recognized as the Bio-Based Chemical Innovation of the Year at the 2017 European Bio-Based Innovation Awards.<\/p>\n\n\n\n

Cyrene\u2122 solvent is available globally. For more information about Cyrene\u2122 and other green chemistry initiatives from Merck, visit the Greener Alternatives page here<\/a>.<\/p>\n\n\n\n

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About the Corporate Responsibility Efforts of the Life Science Business of Merck <\/strong><\/h3>\n\n\n\n

Through its Corporate Responsibility initiatives, the Life Science business of Merck harnesses the collective expertise, passion and energy of employees to minimize its environmental footprint and positively impact communities around the world.<\/p>\n\n\n\n

The Life Science business of Merck is uniquely positioned to solve the toughest problems in life science through its efforts aligned with strengths in research, innovation and collaboration with the global scientific community. This helps differentiate its business and provides a competitive edge for its customers, while accelerating access to health for people everywhere. The Life Science business of Merck demonstrates its commitment to Corporate Responsibility through extensive programs in three main areas: Greener Products and Solutions\u2014which includes Design for Sustainability, Green Chemistry, Packaging and Recycling initiatives; Employee and Community Engagement; and Sustainable Operations.<\/p>\n\n\n\n

About Merck<\/strong><\/h3>\n\n\n\n

Merck, a leading science and technology company, operates across healthcare, life science and performance materials. Around 52,000 employees work to make a positive difference to millions of people\u2019s lives every day by creating more joyful and sustainable ways to live. From advancing gene- editing technologies and discovering unique ways to treat the most challenging diseases to enabling the intelligence of devices \u2013 Merck is everywhere. In 2018, Merck generated sales of \u20ac14.8 billion in 66 countries.<\/p>\n\n\n\n

Scientific exploration and responsible entrepreneurship have been key to Merck\u2019s technological and scientific advances. This is how Merck has thrived since its founding in 1668. The founding family remains the majority owner of the publicly listed company. Merck holds the global rights to the \u201cMerck\u201d name and brand. The only exceptions are the United States and Canada, where the business sectors operate as EMD Serono in healthcare, MilliporeSigma in life science, and EMD Performance Materials.<\/p>\n","protected":false},"excerpt":{"rendered":"

Merck, a leading science and technology company, today launched Cyrene\u2122 \u2014 a sustainable dipolar aprotic solvent, produced in two steps from a renewable cellulose source. The bio-derived alternative was created in response to the need for solvents to meet stricter regulation requirements for both employee safety and environmental sustainability. The new product targets the rising […]<\/p>\n","protected":false},"author":59,"featured_media":143638,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","nova_meta_subtitle":"New bio-derived product is a safer, more sustainable alternative for Dimethylformamide and N-Methyl-2-pyrrolidone solvents","footnotes":""},"categories":[5572],"tags":[6843,5838,6162,10416,10408,12390,5528],"supplier":[13469,2317,5585,3435,24087,1315],"class_list":["post-143609","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bio-based","tag-biochemicals","tag-bioeconomy","tag-cellulose","tag-circulareconomy","tag-greenchemistry","tag-solvents","tag-sustainability","supplier-circa-group","supplier-european-commission","supplier-european-union","supplier-merck-co-inc","supplier-university-of-st-andrews-2","supplier-university-of-york-uk"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/143609","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/59"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=143609"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/143609\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media\/143638"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=143609"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=143609"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=143609"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=143609"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}