{"id":133800,"date":"2023-10-31T07:12:00","date_gmt":"2023-10-31T06:12:00","guid":{"rendered":"https:\/\/renewable-carbon.eu\/news\/?p=133800"},"modified":"2023-10-26T10:45:30","modified_gmt":"2023-10-26T08:45:30","slug":"emerging-granular-hydrogel-bioinks-to-improve-biological-function-in-bioprinted-constructs","status":"publish","type":"post","link":"https:\/\/renewable-carbon.eu\/news\/emerging-granular-hydrogel-bioinks-to-improve-biological-function-in-bioprinted-constructs\/","title":{"rendered":"Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs"},"content":{"rendered":"\n\n\n<h2 class=\"wp-block-heading\" id=\"secst0005\">Highlights<\/h2>\n\n\n\n<ul class=\"wp-block-list\" id=\"l0005\">\n<li>A significant challenge in bioprinting is balancing cell functions and printability: improving printability often results in reduced biological function.<\/li>\n\n\n\n<li>Granular hydrogel bioinks enable bulk microporosity in bioprinted constructs, which enhance cell growth and diffusion of nutrients and oxygen, thereby overcoming limitations in current bioinks.<\/li>\n\n\n\n<li>The modular nature of granular bioinks enables vast control over porosity, printability, resolution, scaffold degradation, heterogeneity, and cell loading.<\/li>\n\n\n\n<li>Stability of granular bioprinted constructs critically depends on the inter- and intraparticle crosslinking. Thus, the design of a granular bioink crosslinking approach requires significant consideration to maintain construct stability.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"secst1021\">Abstract<\/h2>\n\n\n\n<p>Advancements in 3D bioprinting have been hindered by the trade-off between printability and biological functionality. Existing bioinks struggle to meet both requirements simultaneously. However, new types of bioinks composed of densely packed microgels promise to address this challenge. These bioinks possess intrinsic porosity, allowing for cell growth, oxygen and nutrient transport, and better immunomodulatory properties, leading to superior biological functions. In this review, we highlight key trends in the development of these granular bioinks. Using examples, we demonstrate how granular bioinks overcome the trade-off between printability and cell function. Granular bioinks show promise in 3D bioprinting, yet understanding their unique structure\u2013property\u2013function relationships is crucial to fully leverage the transformative capabilities of these new types of bioinks in bioprinting.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Highlights Abstract Advancements in 3D bioprinting have been hindered by the trade-off between printability and biological functionality. Existing bioinks struggle to meet both requirements simultaneously. However, new types of bioinks composed of densely packed microgels promise to address this challenge. These bioinks possess intrinsic porosity, allowing for cell growth, oxygen and nutrient transport, and better [&#8230;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","nova_meta_subtitle":"The properties of individual microgels within the granular bioink govern the overall printability, shape fidelity, and biological function of constructs","footnotes":""},"categories":[5572],"tags":[10588,16380,22925,14436,15864],"supplier":[11310],"class_list":["post-133800","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-3dprinting","tag-biobased","tag-bioprinting","tag-hydrogel","tag-inks","supplier-cell-magazine"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/133800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=133800"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/133800\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=133800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=133800"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=133800"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=133800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}