NGIB based on engineered halophiles has been successfully used for the production of polyhydroxyalkanoates and other compounds with reduced energy and freshwater consumption.<\/p>\n\n\n\n
Synthetic biology tools and approaches have been developed for extremophiles to enable static and dynamic optimization of metabolic pathways.<\/p>\n\n\n\n
Extremophile fermentation has simplified whole bioproduction processes including sterilization, aeration, and downstream processing.<\/p>\n\n\n\n
Microbial biomanufacturing, powered by the advances of synthetic biology, has attracted growing interest for the production of diverse products. In contrast to conventional microbes, extremophiles have shown better performance for low-cost production owing to their outstanding growth and synthesis capacity under stress conditions, allowing unsterilized fermentation processes. We review increasing numbers of products already manufactured utilizing extremophiles in recent years. In addition, genetic parts, molecular tools, and manipulation approaches for extremophile engineering are also summarized, and challenges and opportunities are predicted for non-conventional chassis. Next-generation industrial biotechnology (NGIB) based on engineered extremophiles promises to simplify biomanufacturing processes and achieve open and continuous fermentation, without sterilization, and utilizing low-cost substrates, making NGIB an attractive green process for sustainable manufacturing.<\/p>\n\n\n\n
DOI:https:\/\/doi.org\/10.1016\/j.tibtech.2022.11.010<\/a><\/a>PlumX Metrics<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" NGIB based on engineered halophiles has been successfully used for the production of polyhydroxyalkanoates and other compounds with reduced energy and freshwater consumption. Synthetic biology tools and approaches have been developed for extremophiles to enable static and dynamic optimization of metabolic pathways. Extremophile fermentation has simplified whole bioproduction processes including sterilization, aeration, and downstream processing. […]<\/p>\n","protected":false},"author":105,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"none","nova_meta_subtitle":"Extremophiles are becoming a popular chassis for industrial bioproduction and are becoming competitive with current industrial biotechnology","footnotes":""},"categories":[5572],"tags":[17299,19117],"supplier":[21442],"class_list":["post-120407","post","type-post","status-publish","format-standard","hentry","category-bio-based","tag-biomanufacturing","tag-syntheticbiology","supplier-trends-in-biotechnology"],"_links":{"self":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/120407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/users\/105"}],"replies":[{"embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/comments?post=120407"}],"version-history":[{"count":0,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/posts\/120407\/revisions"}],"wp:attachment":[{"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/media?parent=120407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/categories?post=120407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/tags?post=120407"},{"taxonomy":"supplier","embeddable":true,"href":"https:\/\/renewable-carbon.eu\/news\/wp-json\/wp\/v2\/supplier?post=120407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}